Tissue factor pathway inhibitor: from unknown coagulation inhibitor to major antithrombotic principle

Tissue factor pathway inhibitor: from unknown coagulation inhibitor to major antithrombotic principle.

Acute thrombosis is the major immediate cause of cardiovascular death. The thrombotic process is also a stimulus for developing and continuing the atherosclerotic process. To control thrombus formation has been the aim of scientists during several decades. Exposure of tissue Ž . factor TF to blood, for instance on rupture of atherosclerotic plaques or on endothelial cell damage, may cause acute...

Matrix metalloproteinases cleave tissue factor pathway inhibitor. Effects on coagulation.

The capacity of inflammatory cell-derived matrix metalloproteinases (MMPs) to cleave tissue factor pathway inhibitor (TFPI) and alter its activity was investigated. MMP-7 (matrilysin) rapidly cleaved TFPI to a major 35-kDa product. In contrast, MMP-1 (collagenase-1), MMP-9 (gelatinase B), and MMP-12 (macrophage elastase) cleaved TFPI into several fragments including the 35-kDa band. However, ra...

Reversible regulation of tissue factor-induced coagulation by glycosyl phosphatidylinositol-anchored tissue factor pathway inhibitor.

Endothelial and tumor cells synthesize tissue factor pathway inhibitor (TFPI-1), which regulates tissue factor (TF) function by TF. VIIa. Xa. TFPI-1 quaternary complex formation (where VIIa and Xa are coagulation factors) and by translocation of these complexes into glycosphingolipid-rich microdomains of the cell membrane. Recombinant TFPI-1 added exogenously to cells is targeted to a degradati...

Roles played by tissue factor and tissue factor pathway inhibitor in coagulation

Patients with severe infections almost invariably exhibit evidence of activation of the coagulation system. The lungs are amongst the most frequently affected organs during severe infection and sepsis. The abundant presence of intravascular and extravascular fibrin appears to be a specific hallmark of acute lung injury after sepsis. Tissue factor (TF) is regarded to be the primary initiator of ...

Coagulation Therapy in Hemophilia A and its Relation to Factor VIII Inhibitor in Northeast of Iran